Blueprint is Bryan Johnson's scientific self-experiment to slow and reverse biological ageing. Johnson, the tech entrepreneur who sold Braintree and Venmo for 800 million dollars in 2013, invests over 2 million USD per year on the protocol, with most going to medical tests, advanced therapies and a team of 30 doctors and longevity experts.
His published results are remarkable: biological age reversed by 5.1 years, ageing biologically at only 0.69 years per calendar year, heart function matching a 37-year-old despite being 47. In 2025 the protocol gained further attention through the Netflix documentary Don't Die: The Man Who Wants to Live Forever.
Blueprint Stack – Johnson's own product line: Essential Capsules (24 core nutrients including B-vitamins, Ubiquinol CoQ10, Lithium Orotate and probiotics), Longevity Mix powder (13 ingredients including CaAKG, creatine, glutathione, glycine, magnesium, taurine, vitamin C), NAC plus Ginger plus Curcumin, Omega-3 DHA/EPA (1000-2000 mg).
Other daily supplements: NAD+/NMN/NR (alternated 6 days/week, Johnson has measured intracellular NAD+ at 54.6 uM within optimal 40-100 uM range), Creatine 5g, Fisetin (senolytic flavonoid eliminating zombie cells), Luteolin (anti-inflammatory flavonoid), Lithium Orotate 5 mg ADDED 2026 (after Harvard-led Nature study 2025 on lithium and Alzheimers risk), Vitamin D3, Magnesium Glycinate, Taurine 1-2g, CoQ10/Ubiquinol, Lion's Mane.
Prescription medications (not for use without medical supervision): Acarbose 200 mg, Metformin 500 mg, Plasmalogen 1 ml.
2026 changes: Reduced NMN to 6 days/week, stopped Rapamycin, added low-dose lithium orotate and NDGA.
Cost table: Blueprint Stack official – approx 361 USD/month. Full DIY – approx 600 USD/month. Evidence-based core supplements (creatine, omega-3, vitamin D, magnesium) – 55-90 USD/month. Johnson's total protocol including medical team and tests – approx 167,000 USD/month.
Strongest evidence supplements: 1) Creatine monohydrate 2) Omega-3 DHA/EPA 3) Vitamin D3 4) Magnesium 5) NAD+ precursors NMN/NR 6) Curcumin/Turmeric 7) Taurine 8) Lithium Orotate (new 2026 – Harvard Nature 2025 study).
Realistic starting point: Optimise sleep, diet and exercise (free). Core evidence-based supplements: creatine, omega-3, vitamin D, magnesium. Add NAD+ precursors and Lion's Mane. Consider lithium orotate 5 mg for neuroprotection. Do regular blood tests to understand your biomarkers.
Find all Blueprint supplements at nooplife.com/en/collections/blueprint-and-supplements-protocol
